ARTHUR SACKLER
Arthur, a physician and psychiatrist, founded a research laboratory in 1938, but Arthur's real genius was in marketing and he used this to sell a number of drugs, including the anxiety drug Valium.
He and his younger brothers Mortimer and Raymond owned a small pharmaceutical company called Purdue Frederick which they purchased in 1952. That company produced betadine and earwax.
Arthur remained a relatively silent partner in the old Purdue, dying in 1987 before it became the company we know today.
He never saw any of Purdue's OxyContin profits.
He donated the money to open a number of medical education programs, libraries and museums.
Arthur was inducted into the Medical Marketing Hall of Fame after his death in 1987.
After his death in 1987, his brothers bought Arthur's share of the company.
One of his four children, daughter Elizabeth, has largely taken over his philanthropic work.
Arthur and his heirs have had no involvement with either Purdue Pharma or OxyContin.
MORTIMER SACKLER
Mortimer was an American physician and psychiatrist.
He and his brothers, the elder Arthur and the younger Raymond, published prolific medical research before purchasing a number of pharmaceutical companies, including in 1952, Purdue Frederick.
After Arthur's death, Mortimer and Raymond purchased his descendants' share of Purdue Frederick, and in 1991 they founded the company that would become the pain management giant we know today: Purdue Pharma.
Mortimer became a lavish arts patron from the 1970s onwards, known for his equally extravagant donations and parties.
He died in 2010.
RAYMOND SACKLER
Raymond was a doctor, like his older brothers, and the three were partners in everything until their deaths.
Together with Mortimer, Raymond found success with their opioid painkiller, OxyContin, which became Purdue Pharma's signature drug.
Raymond was milder and more private than his brother Mortimer.
Raymond had two children, Richard and Jonathan, before his death last year.
ILENE SACKLER
Mortimer's eldest daughter with his first wife.
As of December 2016, she was listed as a director of Purdue's sister company, UK-based Napp Pharmaceutical Holdings.
She lives in an apartment she owns on the iconic Upper West Side.
The total value is estimated at more than $122 million.
KATHE SACKLER
Kathe is one of the directors of Napp, a British-based company that also sold OxyContin.
She owns two properties in a Connecticut suburb separated by another property owned by someone else, and she lives in a townhouse on the Upper East Side with her wife, Susan Shack Sackler.
The house was owned by both Raymond and Mortimer. Their children share it.
Kathe and Ilene had a brother, Robert, deceased.
JONATHAN AND RICHARD SACKLER
Raymond's second son by wife Beverly.
Jonathan previously lived with his wife in Greenwich, Connecticut, in a building next to his mother's.
Richard's former childhood home is not far away in neighboring Stamford.
They have a cancer research center named after them at Yale and both have held positions at Purdue.