Unai Emery makes two changes from their win against Arsenal, while Matty Cash and Douglas Luiz come in for Diego Carlos and Morgan Rogers.
That will see Ezri Konsa return to his natural central position, as opposed to the wing-back role he played at the Emirates.
Meanwhile, the hosts involve Yusuf Yazici in attack, the only change after their first leg defeat.
Lille XI: Chevalier, Tiago Santos, Diakite, Yoro, Ismaily, Andre, Bentaleb, Yazici, Haraldsson, Gudmundsson, David.
subtitles: Mannone, Ngrel, Alexsandro, Gomes, Cabella, Ounas, Cavaleiro, Morais, Bouaddi, Toure, Ferrah.
Villa XI: Martinez, Cash, Konsa, Pau, Digne, Luiz, Tielemans, Diaby, Zaniolo, McGinn, Watkins.
subtitles: Olsen, Gauci, Carlos, Lenglet, Duran, Rogers, Kelser-Hayden, Bailey, Iroegbunam, Munroe, Kellyman.