Christina Applegate feels like ‘Humpty Dumpty’ with ‘tiny weird legs’ and ‘big menopausal belly’ as she shares devastating health update

Christina Applegate reveals the devastating physical impact multiple sclerosis has had on her body since her heartbreaking diagnosis in 2021.

In the last episode of her MeSsy podcastApplegate, 52, admitted she felt like “Humpty Dumpty” as she described the muscle atrophy in her legs and the weight gain.

“I have no muscles in my legs, I showed you,” she told co-host Jamie-Lynn Sigler, 43, who also has MS, according to TeFab.

‘I look like Humpty Dumpty. My little weird legs and then my big menopausal belly.’

Applegate has become more of a homebody due to her physical limitations and the side effects of her illness.

“I like being home now because, well, I like being in my bed, but I also don’t want to be in my bed. But once I go out, I’m glad I did,” she told listeners.

Christina Applegate reveals the devastating physical impact multiple sclerosis has had on her body since her heartbreaking diagnosis in 2021; seen in January 2023

Because she can no longer be as active as she used to be, Applegate has sent a “disclaimer” to friends who want to meet up with her.

“I always say, sure, if you want to have lunch, just know — and you need to know this and you can’t be mad at me — that if I tell you right before you come to pick me up that you can’t do it, you can’t be mad. That’s my little disclaimer,” she explained.

“What I’ve done now is I’ve been with everyone I know who wants to do something with me, and they know it’s not going to be a walk through the hills.”

Applegate said she is “not conditioned at this point” to participate in vigorous physical activity because she “[hasn’t] moved.’

She added: ‘For example, if I walk up a hill, my heart starts beating really fast and I think I’m having a heart attack because my heart just… the muscle is no longer there.’

Sigler described himself then as the “most active, athletic” person before her own MS diagnosis at age 20.

“If everyone was going to play a sport, I would stick with it until the end,” the New York native said.

“That was my life. I just always wanted to be doing something, and out and about, I was never home. Now I feel like I’m always home.”

Applegate publicly announced she had been diagnosed with MS in August 2021, months after hearing the news from her doctor.

Meanwhile, Sigler kept her 2002 diagnosis secret for 14 years before going public with it in 2016.

‘Multiple sclerosis (MS) is a long-term (chronic) disease of the central nervous system’, according to Johns Hopkins Medicine.

An autoimmune disease is a devastating condition in which the body mistakenly attacks itself.

It is said that ‘MS is an unpredictable disease that affects people in different ways.’

Some people experience mild symptoms, while others completely lose their ability to see, write, speak, or walk clearly when communication between the brain and other parts of the body is disrupted.

In the latest episode of her MeSsy podcast, Applegate, 52, admitted she felt like

In the latest episode of her MeSsy podcast, Applegate, 52, admitted she felt like “Humpty Dumpty” as she described the muscle atrophy in her legs and the weight gain

Christina Applegate feels like Humpty Dumpty with tiny weird legs

“I have no muscles in my legs, I showed you,” she told co-host Jamie-Lynn Sigler, 43, who also has MS, according to TooFab. “I look like Humpty Dumpty. My little weird legs and then my big menopausal belly”; seen in February 2023

Due to her physical limitations and the side effects of her illness, Applegate has become more of a homebody over the past three years; seen in January 2024

Due to her physical limitations and the side effects of her illness, Applegate has become more of a homebody over the past three years; seen in January 2024

Her co-host Jamie-Lynn Sigler, 43, described herself as the

Her co-host Jamie-Lynn Sigler, 43, described herself as the “most active, athletic” person before her own MS diagnosis at age 20; seen in June 2024

Wanting to make a difference and connect with others dealing with serious illness, Applegate reached out to Sigler to hear about her experiences with MS, which eventually led to the creation of their podcast.

In the MeSsy podcast, the stars of Married With Children and The Sopranos make themselves “vulnerable to the unexpected events of life… theirs just happens to have MS,” the podcast’s homepage reads.

‘Join them each week as they self-reflect, learn, laugh and grow through their own raw and often hilarious conversations with each other, friends, fellow actors and the people who help them through life’s chaos.’